Communication inside the body is happening in two ways.
1) Natural triggering - such as reflex action, antibody generation etc. where the neurons are the carriers for the information transfer.
2) Induced triggering – such as targeted drug delivery and isotropic activation analysis where the nano materials are having very significant role, where as in first case bio macro molecules are playing the significant role.
In isotropic activation analysis a particular isotopic substitution will be responsible for the communication. The medium of communication will be always an aqueous system inside the body. Hence not only the size but shape also matters. Nano devices to be used in vivo should be designed in such a way that there will be minimum amount of friction.
Even though nanotechnology is in its infancy, scientists & technologists will make use of it in all phases of life like never before. In future, they hope to mould quantum dots to track specific chemical reactions inside nuclei, such as how proteins assist repair DNA after irradiation. They have already visualized the ‘dots’ journey from the area surrounding the nucleus to inside the nucleus, an achievement that opens the door for real-time scrutiny of nuclear trafficking mechanisms. They also anticipate targeting other cellular organelles as well the nucleus, such as mitochondria and golgi bodies. Since, quantum dots emit different colours of light based on their size; they can be used to observe the transfer of material between cells.

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